Aved-Multi - How it Works

Background

While the prevalence of premenstrual syndrome is difficult to ascertain, approximately 75% of all women complain of some PMS-related symptoms². A study, with over 870 women questioned³, reported serious symptoms plague over 8% of women; younger and more active women, with longer menses were more likely to suffer PMS, while overall the most positive correlation was with stress. Common PMS complaints are nervousness, depression, fatigue, insomnia, headaches and minor body-aches.

Two common behaviors which might be avoided to reduce the severity of PMS are drinking red wine and abstinence from caffeine. Red wine, rather than other strong drinks, seems causative for migraine headaches; the effect seems to be both immediate and severe⁴. On the other hand, reducing one’s daily coffee or tea may also bring on headaches and hence exacerbate PMS⁵. There is some evidence that dairy products should be avoided during this period to reduce the symptom of water retention.

Proper nutrition seems to play a positive role in relieving some of the problems of PMS. A population of women with PMS display increased carbohydrate tolerance and low red-cell magnesium⁶- typical symptoms of glucose intolerance. High glucose levels coupled with low intracellular glucose levels often manifests as irritable behavior while low levels of plasma magnesium are associated with glucose intolerance and insulin resistance⁷. The vitamins B6 and E encourage the release of progesterone into the bloodstream and raise progesterone levels. This tends to relax a woman with cessation of some anxiety and nervousness⁶. Evidence is also accumulating that several minerals are important for tissue remodeling during and before menstruation⁸. Zinc is the crucial active site catalyst for an entire host of matrix metalloproteinases which are critical for angiogenesis and other processes of tissue remodeling. Zinc is also the catalytic metal for the key enzyme, aminopeptidase A, the proteolytic enzyme converting angiotension II (AngII) into angiotension III – AngII plays a pivotal role in vasorestriction of the endometrial arteries before and during menses. Zinc, as well as iron deficiencies, has been observed for young women who do not supplement their diets⁹. Zinc and iron tissue stores of young women are quite low compared with post-menopausal women and men¹⁰, and should be supplemented to avoid chronic problems from common deficiencies such as anemia.

1. Reimer, R.A., Debert, C.T., House, J.L. and Poulin, M.J. (2005). Dietary and metabolic differences in pre- versus postmenopausal women taking or not taking hormone replacement therapy. Physiology & Behavior 84(2): 303-312.
2. Barnhart, K.T., Freeman, E.W. and Sondheimer, S.J. (1995). A clinician’s guide to the premenstrual syndrome. Medical Clinics of North America 79: 1457-1472.
3. Deuster, P.A., Adera, T. and South-Paul, J. (1999). Biological, social and behavioral factors associated with premenstrual syndrome. Archives of Family Medicine 8(2): 122-128.
4. Littlewood, J.T., Gibb, C., Glover, V., Sandler, M. Davies, P.T. and Rose, F.C. (1988). Red wine as a cause of migraine. Lancet 12(1): 558-559.
5. Silverman, K., Evans, S.M., Strain, E.C. Griffiths, R.R. (1992). Withdrawal syndrome after the double-blind cessation of caffeine consumption. New England Journal of Medicine 327(16): 1160-1161.
6. Abraham, G.E. (1983). Nutritional factors in the etiology of the premenstrual tension syndromes. Journal of Reproductive Medicine 28(7): 446-464.
7. Rosolova, H., Mayer, O. and Reaven, G. (1997). Effect of variations in plasma magnesium concentration on resistance to insulin-mediated glucose disposal in nondiabetic subjects. J. Clin. Endocrinol. Metab. 82(11): 3793-3785.
8. Freitas, et al. (1999). Expression of metalloproteinases and their inhibitors in blood vessels in human endometrium. Biology of Reproduction 61: 1070-1082. Ando, H. et al. (2002). Premenstrual disappearance of aminopeptidase A in endometrial stromal cells around endometrial spiral arteries/arterioles during the decidual change. Journal of Clinical Endocrinology & Metabolism 87(5): 2303-2309.
9. Gibson, R.S., Heath, A.L. and Ferguson, E.L. (2002). Risk of suboptimal iron and zinc nutriture among adolescent girls in Australia and New Zealand: causes, consequences and solution. Asia Pacific Journal of Clinical Nutrition 11Suppl. 3: S543-552.
10. Hess, F.M., King, J.C. and Margen, S. (1977). Zinc excretion in young women on low zinc intakes and oral contraceptive agents. Journal of Nutrition 107(9): 1610-1620.

Supplement Facts - PMS Multi Tab

Quality Assurance Statement - Anabolic Laboratories

Founded in 1924, Anabolic Laboratories formulates and manufactures clinical nutrition products. Our expertise in pharmaceutical manufacturing, patient programs, and clinician training sets the standard for health care professionals.

At Biossential Nutrition, we pride ourselves in offering the best products available to our customers. Offering the highest quality products & individual ingredients, as well as ensuring our products are effective & work as advertised, are the mains goals we strive to achieve with our product offerings.

Why We Recommend Anabolic Laboratories Nutritional Supplements

History

Anabolic Laboratories was founded as a nutritional products company in 1924 and became a pharmaceutical manufacturer in 1940. Anabolic Laboratories is one of the oldest manufacturers of nutritional products in the world.

Standards

As a pharmaceutical manufacturing operation, the standards used for raw materials, production and finished product testing exceed the new requirements for nutritional product manufacturing.

Quality

Pharmaceutical standards of manufacturing provide nutritional products with label accuracy, potency and purity as dictated by the USFDA (United States Food & Drug Administration).

Formulas

A nutritional program and clinical formulas that are based on the specifications used in the scientific research.

The Need To Consider Quality:

Of the magnesium supplements tested by ConsumerLab.com, 25% failed to meet quality standards. One magnesium supplement contained only 45.4% of labeled amount, despite boasting a "GMP" (Good Manufacturing Practices) seal on its label, and another supplement provided only 28.8% of the labeled amount.
Reference: ConsumerLab.com, Magnesium Supplement Reviews and Quality Ratings, Posted 5/19/09

Tests by ConsumerLab.com have found multivitamins that were short on ingredients, failed to dissolve properly, or were contaminated with heavy metals.
ConsumerLab.com, New Product Review: Multivitamin and Multimineral Supplements, Posted 4/1/09

The Food and Drug Administration (FDA) has found that manufacturing problems have been associated with dietary supplements. Products been recalled because of microbiological, pesticide, and heavy metal contamination, and because they do not contain the dietary ingredients they are represented to contain, or they contain more or less than the amount of dietary ingredient claimed on the label.
Reference: June 22, 2007, FDA @ http://www.cfsan.fda.gov/~dms/dscgmps7.html