PRO-ENZ™ - How it Works

Background

Inflammation is a major cause of pain for many people². Though progress can often be made using physical therapy and adjustments, diet can play a key role aiding the patient to quickly return to a healthy anti-inflammatory state. There are several different mechanisms by which various nutritional ingredients function to help control pain and speed the return to normalcy.

Prostaglandins, especially the E2 prostaglandins, are the hormone-like substances (rather like cytokines) responsible for local inflammation and systemic fever. The E2 family of signals are formed from arachidonic acid - the omega-6 fatty acids common to the modern, fast-food, western diet – which are immediately liberated from the cell walls of damaged tissues by the destructive forces of trauma. Trauma may either be mechanical, from the blunt force of impact or puncture, or from the twist and pulls of overexertion and overextension, all leading to damaged tissues. The nearly instantaneous formation of prostaglandins is catalyzed by enzymes called cyclo-oxygenases (COX) working on arachidonic acid from ruptured cell walls. Curcumin (the active ingredient from turmeric), ginger extract, ursolic acid (from rosemary) and boswellia extracts all discourage the biosyntheses of COX enzymes at the level of transcription³. Lowering the concentrations of cyclo-oxygenases depresses the tissue concentrations of inflammatory prostaglandins and greatly aids the patient’s return to healthy levels of these hormones. Curcumin, especially, has been shown to be a useful inhibitor of the COX⁴ and LOX⁵ enzymes and also functions to inhibit CNS stimulated, generalized pain⁶.

Excessive tissue oxidation almost always occurs at sites of tissue trauma and is exacerbated by the retardation of blood circulation within inflamed tissues. With retarded circulation greatly slowing the recovery process, a self-reinforcing cycle of inflammation-caused pain often arises. We have included the newly discovered ursolic acid which has been shown quite potent at encouraging a return to tissue normalcy from an inflamed, unhealthy state⁷. Ursolic acid and the classic lemon bioflavonoid complex - containing powerful antioxidants - help mitigate self, reinforced inflammation and help return the surrounding tissues to health.

Bromelain is an extract derived from pineapples. It contains an ensemble of closely related, vegetable proteases (protein cleaving catalysts) which exhibit gentle anti-edematous, anti-inflammatory, antithrombotic, and some fibrinolytic-like activities. Having very few side effects, bromelain has been used clinically for many decades to aid recovery. The four most important bromelain enzymes are all “cysteine-active site” enzymes, and these all require antioxidants such as vitamin C or bioflavonoids, to maintain maximal activities.

References

1. Bucci LR (1994). Nutrition applied to injury rehabilitation and sports medicine. CRC Press, Inc. Boca Raton, FL
2. Seaman DR (2002). The diet-induced pro-inflammatory state: a cause of chronic pain and other degenerative diseases? J. Manipulative Physiol. Ther. 25: 168-179.
3. Aggarwal BB and Shishodia S (2004). Suppression of the NF-kB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann. NY Acad. Sci. 1030: 434-441.
4. Cho JW et al. (2005). Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratocytes (HaCaT) by inhibiting activation of AP-1. Exp. Mol. Med. 37: 186-192.
5. Prasad NS et al. (2005). Spice phenolics inhibit human PMNL 5-lipoxygenase. Prostaglandins Leuko. Essent. Fatty Acids 70: 521-528.
6. Tomita M et al. (2005). Differential regulation of Abeta42-induced neuronal C1q synthesis and microglial activation. J. Neuroinflammation 2: 1-7, www.jneuroinflammation.com/content/2/1/8 Novotny C, Vachalkova A and Biggs D (2001). Ursolic acid: Minireview. Neoplasma 48: 241-246.

Supplement Facts - PRO-ENZ™

Quality Assurance Statement - Anabolic Laboratories

Founded in 1924, Anabolic Laboratories formulates and manufactures clinical nutrition products. Our expertise in pharmaceutical manufacturing, patient programs, and clinician training sets the standard for health care professionals.

At Biossential Nutrition, we pride ourselves in offering the best products available to our customers. Offering the highest quality products & individual ingredients, as well as ensuring our products are effective & work as advertised, are the mains goals we strive to achieve with our product offerings.

Why We Recommend Anabolic Laboratories Nutritional Supplements

History

Anabolic Laboratories was founded as a nutritional products company in 1924 and became a pharmaceutical manufacturer in 1940. Anabolic Laboratories is one of the oldest manufacturers of nutritional products in the world.

Standards

As a pharmaceutical manufacturing operation, the standards used for raw materials, production and finished product testing exceed the new requirements for nutritional product manufacturing.

Quality

Pharmaceutical standards of manufacturing provide nutritional products with label accuracy, potency and purity as dictated by the USFDA (United States Food & Drug Administration).

Formulas

A nutritional program and clinical formulas that are based on the specifications used in the scientific research.

The Need To Consider Quality:

Of the magnesium supplements tested by ConsumerLab.com, 25% failed to meet quality standards. One magnesium supplement contained only 45.4% of labeled amount, despite boasting a "GMP" (Good Manufacturing Practices) seal on its label, and another supplement provided only 28.8% of the labeled amount.
Reference: ConsumerLab.com, Magnesium Supplement Reviews and Quality Ratings, Posted 5/19/09

Tests by ConsumerLab.com have found multivitamins that were short on ingredients, failed to dissolve properly, or were contaminated with heavy metals.
ConsumerLab.com, New Product Review: Multivitamin and Multimineral Supplements, Posted 4/1/09

The Food and Drug Administration (FDA) has found that manufacturing problems have been associated with dietary supplements. Products been recalled because of microbiological, pesticide, and heavy metal contamination, and because they do not contain the dietary ingredients they are represented to contain, or they contain more or less than the amount of dietary ingredient claimed on the label.
Reference: June 22, 2007, FDA @ http://www.cfsan.fda.gov/~dms/dscgmps7.html